oxidized glutathione structure of GSH (reduced glutathione, left) and of GSSG (oxidized Cited in 3 publications L-Glutathione vs. oxidized vs. Reduced

In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

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